Biogenesis and Biochemistry

An authoritative and up-to-date collection of resources covering the ubiquitous iron-sulfur cluster-containing proteins

In Iron-Sulfur Clusters: Biogenesis and Biochemistry, a team of distinguished researchers delivers an incisive and practical discussion of the assembly and role of metalloproteins containing an iron atom in a mononuclear or binuclear metal-active site, or where the assembly and final activity of the enzyme depends on an Fe-S cluster containing protein.

The book examines the crosstalk in the assembly of metal-active sites and the roles played by various metal ions in polynuclear metalloclusters. It also describes metal homeostasis and trafficking in a cellular context and explains why the availability of metal ions is tightly regulated.

Of particular interest to chemists working with iron-sulfur (Fe-S) clusters in biology, biochemistry, pharmaceuticals, and drug synthesis, the book also contains:

• A thorough introduction to the biosynthesis of hydrogenase cofactors and hydrogenase reaction mechanisms
• Comprehensive explorations of the reaction mechanisms of molybdoenzymes, including sulfite oxidase, aldehyde oxidase, and formate dehydrogenase
• Practical discussions of the biosynthesis of Fe-S clusters in prokaryotes and eukaryotes
• Complete examinations of the insertion of Fe-S clusters and the biosynthesis of Moco and FeMoco
• An overview of the chemical, crystallographic, spectroscopic and theoretical methods commonly used to characterize Fe-S clusters.

Perfect for biochemists and protein, pharmaceutical, bioinorganic, and organic chemists, Iron-Sulfur Clusters will also be useful for food and environmental chemists, as well as professionals working in the pharmaceutical industry.