For young Sheldon Cooper, it isn't easy growing up in East Texas. Being a once-in-a-generation mind capable of advanced mathematics and science isn't always helpful in a land where church and football are king. And while the vulnerable, gifted and somewhat naïve Sheldon (Iain Armitage) deals with the world, his very normal family must find a way to deal with him. His father, George (Lance Barber), is struggling to find his way as a high school football coach and as father to a boy he doesn't understand. Sheldon's mother, Mary (Zoe Perry), fiercely protects and nurtures her son in a town where he just doesn't fit in. Sheldon's older brother, Georgie (Montana Jordan), does the best he can in high school, but it's tough to be cool when your odd younger brother is already in college. Sheldon's twin sister, Missy (Raegan Revord), sometimes resents all the attention Sheldon gets, but also remains the one person who can reliably tell Sheldon the truth. Finally, there's Sheldon's beloved Meemaw (Annie Potts), his foul-mouthed, hard-drinking Texas grandmother who is very supportive of her grandson and his unique gifts.