Monomaniacal witch hunter Lord Edward Whitman (Vincent Price) cruelly persecutes the peasants in his corner of Elizabethan England, manufacturing charges and meting out punishment without regard to justice. While trying to wipe out a coven of witches, he fails to take into account the possibility that real witches might have real power. He is unprepared when Oona (Elisabeth Bergner), the head of the coven, transforms a trusted member of Whitman's household into a vehicle of demonic vengeance. The film Horror Express tells the story of Alexander Saxton (Christopher Lee), a brilliant British anthropologist researching in the Russian Far East, boards the Trans-Siberian Express with his latest discovery, a frozen specimen he hopes to prove is the missing link. But en route to Europe, passengers begin to turn up dead, and terror engulfs the train as Saxton and his partner, Dr. Wells (Peter Cushing), struggle to contain a mysterious - and increasingly murderous - force with the power to control minds.