{"product_id":"9781032922058-bayesian-adaptive-methods-for-clinical","title":"Bayesian Adaptive Methods for Clinical Trials","description":"\u003cmeta content=\"text\/html; charset=utf-8\" http-equiv=\"Content-Type\"\u003e\u003cp\u003e\u003cspan\u003eWritten by leading pioneers of Bayesian clinical trial designs, this book explores the growing role of Bayesian thinking in clinical trial analysis. Covering Phase I, II, and III clinical trials, it establishes the basic principles before extending them to specific phases and endpoints. The authors also discuss special topics that span different\u003cbr\u003e\u003cp\u003eAlready popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimer’s disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, \u003cstrong\u003eBayesian Adaptive Methods for Clinical Trials\u003c\/strong\u003e explores the growing role of Bayesian thinking in the rapidly changing world of clinical trial analysis.\u003c\/p\u003e\n\u003cp\u003eThe book first summarizes the current state of clinical trial design and analysis and introduces the main ideas and potential benefits of a Bayesian alternative. It then gives an overview of basic Bayesian methodological and computational tools needed for Bayesian clinical trials. With a focus on Bayesian designs that achieve good power and Type I error, the next chapters present Bayesian tools useful in early (Phase I) and middle (Phase II) clinical trials as well as two recent Bayesian adaptive Phase II studies: the BATTLE and ISPY-2 trials. In the following chapter on late (Phase III) studies, the authors emphasize modern adaptive methods and seamless Phase II–III trials for maximizing information usage and minimizing trial duration. They also describe a case study of a recently approved medical device to treat atrial fibrillation. The concluding chapter covers key special topics, such as the proper use of historical data, equivalence studies, and subgroup analysis.\u003c\/p\u003e\n\u003cp\u003eFor readers involved in clinical trials research, this book significantly updates and expands their statistical toolkits. The authors provide many detailed examples drawing on real data sets. The R and WinBUGS codes used throughout are available on supporting websites.\u003c\/p\u003e\n\u003cp\u003eScott Berry talks about the book on the CRC Press YouTube Channel.\u003c\/p\u003e\n\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"Rarewaves","offers":[{"title":"Default Title","offer_id":55447224680822,"sku":"9781032922058","price":58.38,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0092\/7504\/8033\/files\/orig_36639975.jpg?v=1760681508","url":"https:\/\/www.rarewaves.com\/products\/9781032922058-bayesian-adaptive-methods-for-clinical","provider":"Rarewaves.com","version":"1.0","type":"link"}