{"product_id":"9781032079646-mammalian-heme-peroxidases","title":"Mammalian Heme Peroxidases","description":"\u003cmeta content=\"text\/html; charset=utf-8\" http-equiv=\"Content-Type\"\u003e\u003cp\u003e\u003cspan\u003eDiverse Roles in Health and Disease\u003cbr\u003eMammalian heme peroxidase enzymes are critical for immune responses and disease prevention. Although beneficial, overproduction drives development of pathologies, by triggering the initiation of stress-related cell damage and dysfunction. This book highlights the roles of mammalian heme peroxidases, and their involvement in immunity and disease.\u003cbr\u003e\u003cp\u003eMammalian heme peroxidase enzymes play a critical role in innate immune responses and disease prevention. The formation of potent chemical oxidants is essential to this protective physiologic activity in immunity. Although highly beneficial in the context of immune defense, it is now well established that peroxidases and their overproduction of oxidants contribute to the initiation and persistence of many chronic inflammatory conditions in the cardiovascular, neurologic, respiratory, renal, and gastrointestinal systems. Peroxidasins, a protein family related to heme peroxidases, play a novel role in tissue biogenesis and matrix assembly, which are also attracting attention in different pathological contexts. Given the diverse roles of mammalian heme peroxidases and the breadth and incidence of pathologies associated with these enzymes, there has been significant interest in modulating peroxidase activity as a therapeutic strategy. This book highlights recent developments in our understanding of the chemistry, biochemistry and biological roles of mammalian peroxidases and their associated oxidants, their involvement in both innate immunity and chronic inflammatory disease in a variety of end organs, and potential therapeutic approaches to modulate and prevent damaging reactions.\u003c\/p\u003e\n\u003cp\u003eKey Features\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e \u003c\/p\u003e \u003c\/li\u003e\n\u003cli\u003eStructure and biosynthesis of mammalian peroxidases\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e \u003c\/p\u003e \u003c\/li\u003e\n\u003cli\u003eReactivity of hypohalous acids with biological substrates\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e \u003c\/p\u003e \u003c\/li\u003e\n\u003cli\u003ePeroxidases in innate immunity\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e \u003c\/p\u003e \u003c\/li\u003e\n\u003cli\u003ePeroxidases in human pathology\u003c\/li\u003e\n\u003cli\u003eModulation of peroxidase-induced biological damage\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"Rarewaves","offers":[{"title":"Default Title","offer_id":56517618008438,"sku":"9781032079646","price":62.51,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0092\/7504\/8033\/files\/stand_37653979.jpg?v=1762246233","url":"https:\/\/www.rarewaves.com\/products\/9781032079646-mammalian-heme-peroxidases","provider":"Rarewaves.com","version":"1.0","type":"link"}