{"product_id":"9780470281741-enzyme-inhibition-in-drug-discovery-and-development","title":"Enzyme Inhibition in Drug Discovery and Development","description":"\u003cmeta content=\"text\/html; charset=utf-8\" http-equiv=\"Content-Type\"\u003e\u003cp\u003e\u003cspan\u003eThe Good and the Bad\u003cbr\u003eThis book covers the science and approaches of enzyme inhibition applied in drug discovery and drug development, including both pharmacology and pharmacokinetic aspects of enzyme inhibition.\u003cbr\u003eThe science and applied approaches of enzyme inhibition in drug discovery and development  \u003cp\u003eOffering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, \u003ci\u003eEnzyme Inhibition in Drug Discovery and Development\u003c\/i\u003e examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development.\u003c\/p\u003e \u003cp\u003eWith chapters written by over fifty leading experts in their fields, \u003ci\u003eEnzyme Inhibition in Drug Discovery and Development\u003c\/i\u003e fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the \"good\" inhibitions—desirable pharmacological effects—and \"bad\" inhibitions—drug–drug interactions and toxicity. The book discusses:\u003c\/p\u003e \u003cul\u003e\n\u003cli\u003e \u003cp\u003eThe drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment\u003c\/p\u003e \u003c\/li\u003e\n\u003cli\u003e \u003cp\u003eThe manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions\u003c\/p\u003e \u003c\/li\u003e\n\u003cli\u003e \u003cp\u003eThe inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway\u003c\/p\u003e \u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eThrough this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.\u003c\/p\u003e\n\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"Rarewaves","offers":[{"title":"Default Title","offer_id":55179025678710,"sku":"9780470281741","price":235.92,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0092\/7504\/8033\/files\/orig_28027144.jpg?v=1737601994","url":"https:\/\/www.rarewaves.com\/products\/9780470281741-enzyme-inhibition-in-drug-discovery-and-development","provider":"Rarewaves.com","version":"1.0","type":"link"}